The collage of Science is one of the oldest and largest colleges at Muta’h University. The establishment of the College came as an extension of the Department of Natural Sciences, which was established in 1984 with only 100 students and five faculty member. The college has witnessed a steady growth since its establishment,  taken its current form since 1990 .
The collage comprising four departments: Department of Mathematics and Statistics, Department of Biology,  Department of Physics and Department of Chemistry. Each department  offering both undergraduate and graduate programs, serving more than two thousand students of the college in addition to its largest role in teaching basic sciences to students of other colleges of university.                                    During the last three years the College of Science had taken confident steps towards development and upgrading all undergraduates program to keep up with modern scientific achievement. These steps improved the educational outcome in term of students’ knowledge and experience which required to compete in the labor market and enable them to serve society effectively.
Furthermore, the college's strategic plan is directed toward establishing an attractive cross-disciplinary academic program meet the needs of the national labor market.

Research is another bright side of the college: The college of science is committed to work continuously providing an adequate academic environment, conductive to its faculty achieving highest level of academic and research performance. Persuade faculty members on the scientific research by providing scientific equipment, overcoming obstacles.

The college witnessed a number of scientific activities during the passing years, including the establishment of several workshops and teaching courses for students in the field of languages, public safety and networking with the health and industrial sector in the region.

To complete the aspect of development administrative needs attention to activate the automation of administrative transaction and improve the efficiency of administrative staff by encouraging them to enroll in appropriate training courses.​​